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1

A Phase I trial of h-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

C. Casey Cunningham, Jon T. Holmlund, Richard S. Geary, T. Jesse Kwoh, Andrew Dorr, Joseph F. Johnston, Brett Monia, John Nemunaitis

Journal:

Year:

2001

Language:

english

File:

PDF, 84 KB

english, 2001

2

Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis

Kanji Yamaguchi, Liu Yang, Shannon McCall, Jiawen Huang, Xing Xian Yu, Sanjay K. Pandey, Sanjay Bhanot, Brett P. Monia, Yin-Xiong Li, Anna Mae Diehl

Journal:

Year:

2008

Language:

english

File:

PDF, 3.20 MB

english, 2008

3

Therapeutic potential for microRNAs

Christine C. Esau, Brett P. Monia

Journal:

Advanced Drug Delivery Reviews

Year:

2007

Language:

english

File:

PDF, 530 KB

english, 2007

4

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

Yoichi Nagata, Keng-Hsueh Lan, Xiaoyan Zhou, Ming Tan, Francisco J. Esteva, Aysegul A. Sahin, Kristine S. Klos, Ping Li, Brett P. Monia, Nina T. Nguyen, Gabriel N. Hortobagyi, Mien-Chie Hung, Dihua Yu

Journal:

Year:

2004

Language:

english

File:

PDF, 511 KB

english, 2004

5

Telomerase Inhibition, Telomere Shortening, and Decreased Cell Proliferation by Cell Permeable 2‘- O -Methoxyethyl Oligonucleotides

Chen, Zhi, Monia, Brett P., Corey, David R.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 190 KB

english, 2002

6

Antisense raf Oligodeoxyribonucleotide Is a Radiosensitizer In Vivo

GOKHALE, PRAFULLA C., McRAE, DONALD, MONIA, BRETT P., BAGG, ADAM, RAHMAN, AQUILUR, DRITSCHILO, ANATOLY, KASID, USHA

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1999

Language:

english

File:

PDF, 16.51 MB

english, 1999

7

A phase 3 clinical trial with ISIS-TTRRx, a 2nd-generation antisense oligonucleotide targeting transthyretin (TTR), for the treatment of TTR amyloid cardiomyopathy

Millns, Helen, Bergemann, Rito, Ackermann, Elizabeth, Monia, Brett, Lukas, Mary

Journal:

Orphanet Journal of Rare Diseases

Year:

2015

Language:

english

File:

PDF, 265 KB

english, 2015

8

Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines

Holmes-Hampton, Gregory P., Crooks, Daniel R., Haller, Ronald G., Guo, Shuling, Freier, Susan M., Monia, Brett P., Rouault, Tracey A.

Journal:

Human Molecular Genetics

Year:

2016

Language:

english

File:

PDF, 1.25 MB

english, 2016

9

Treatment of transthyretin (TTR) amyloid cardiomyopathy with an antisense oligonucleotide inhibitor of TTR synthesis

Benson, Merrill D, Ackermann, Elizabeth J, Monia, Brett P

Journal:

Orphanet Journal of Rare Diseases

Year:

2015

Language:

english

File:

PDF, 262 KB

english, 2015

10

The ISIS-TTRRx-CS2 phase 3 study in patients with familial amyloid polyneuropathy: Baseline results of the first 100 patients for the NIS, NIS+7 and mNIS+7 using different methods of scoring: identification of consistencies and key differences

Rito Bergemann,Elizabeth Ackermann,Brett Monia…

Journal:

Orphanet Journal of Rare Diseases

Year:

2015

Language:

english

File:

PDF, 265 KB

english, 2015

11

Deletion of Individual Exons and Induction of Soluble Murine Interleukin-5 Receptor-α Chain Expression through Antisense Oligonucleotide-Mediated Redirection of Pre-mRNA Splicing

Karras, James G., McKay, Robert A., Dean, Nicholas M., Monia, Brett P.

Journal:

Molecular Pharmacology

Year:

2000

Language:

english

File:

PDF, 364 KB

english, 2000

12

Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-Induced Goblet Cell Metaplasia in the Adult Murine Lung

Carrer, Michele, Crosby, Jeff R., Sun, Guizhen, Zhao, Chenguang, Damle, Sagar S, Kuntz, Steven G, Monia, Brett P, Hart, Christopher E, Grossman, Tamar R

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2020

Language:

english

File:

PDF, 11.00 MB

english, 2020

13

Inhibition of progression to androgen-independence by combined adjuvant treatment with antisense BCL-XL and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model

Hideaki Miyake, Brett P. Monia, Martin E. Gleave

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 184 KB

english, 2000

14

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

Xing Xian Yu, Susan F. Murray, Sanjay K. Pandey, Sheri L. Booten, Dingjiu Bao, Xiu-Zhen Song, Susan Kelly, Songyuan Chen, Robert McKay, Brett P. Monia, Sanjay Bhanot

Journal:

Year:

2005

Language:

english

File:

PDF, 617 KB

english, 2005

15

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

Kanji Yamaguchi, Liu Yang, Shannon McCall, Jiawen Huang, Xing Xian Yu, Sanjay K. Pandey, Sanjay Bhanot, Brett P. Monia, Yin-Xiong Li, Anna Mae Diehl

Journal:

Year:

2007

Language:

english

File:

PDF, 3.09 MB

english, 2007

16

Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb)

Ivy Jennes, Elena Pedrini, Monia Zuntini, Marina Mordenti, Sahila Balkassmi, Carla G. Asteggiano, Brett Casey, Bert Bakker, Luca Sangiorgi, Wim Wuyts

Journal:

Year:

2009

Language:

english

File:

PDF, 194 KB

english, 2009

17

Bcl-XL is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy

Elisabeth Heere-Ress, Christiane Thallinger, Trevor Lucas, Hermine Schlagbauer-Wadl, Volker Wacheck, Brett P. Monia, Klaus Wolff, Hubert Pehamberger, Burkhard Jansen

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 195 KB

english, 2002

18

Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice

Silvia D'Alessio, Francesca Margheri, Marco Pucci, Angela Del Rosso, Brett P. Monia, Mauro Bologna, Carlo Leonetti, Marco Scarsella, Gabriella Zupi, Gabriella Fibbi, Mario Del Rosso

Journal:

International Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 643 KB

english, 2004

19

Comparison of strategies targeting Raf-1 mRNA in ovarian cancer

Peter Mullen, Fiona McPhillips, Brett P. Monia, John F. Smyth, Simon P. Langdon

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 460 KB

english, 2006

20

Remarkable enhancement of binding affinity of Heterocycle-modified DNA to DNA and RNA. Synthesis, characterization and biophysical evaluation of N2-imidazolylpropylguanine and N2-imidazolylpropyl-2-aminoadenine modified oligonucleotides

Kanda S. Ramasamy, Maryann Zounes, Carolyn Gonzalez, Susan M. Freier, Elena A. Lesnik, Lendell L. Cummins, Richard H. Griffey, Brett P. Monia, P. Dan Cook

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 407 KB

english, 1994

21

Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs

H.Elizabeth Broome, Alice L Yu, Mitch Diccianni, Bruce M Camitta, Brett P Monia, Nicholas M Dean

Journal:

Leukemia Research

Year:

2002

Language:

english

File:

PDF, 189 KB

english, 2002

22

In vivo suppression of Bcl-XL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model

Dean A. Fennell, Margherita V. Corbo, Nicholas M. Dean, Brett P. Monia, Finbarr E. Cotter

Journal:

British Journal of Haematology

Year:

2001

Language:

english

File:

PDF, 303 KB

english, 2001

23

Mcl-1 Antisense Therapy Chemosensitizes Human Melanoma in a SCID Mouse Xenotransplantation Model

Thallinger, Christiane, Wolschek, Markus F, Wacheck, Volker, Maierhofer, Helmut, Günsberg, Patrick, Polterauer, Peter, Pehamberger, Hubert, Monia, Brett P, Selzer, Edgar, Wolff, Klaus, Jansen, Burkhar

Journal:

The Journal of Investigative Dermatology

Year:

2003

Language:

english

File:

PDF, 2.33 MB

english, 2003

24

Loss of PTEN is associated with progression to androgen independence

Jerod Bertram, James W. Peacock, Ladan Fazli, Alice L.-F. Mui, Stephen W. Chung, Michael E. Cox, Brett Monia, Martin E. Gleave, Christopher J. Ong

Journal:

Year:

2006

Language:

english

File:

PDF, 275 KB

english, 2006

25

Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer

Junya Furukawa, Christopher J. Wraight, Susan M. Freier, Eigan Peralta, Lynne M. Atley, Brett P. Monia, Martin E. Gleave, Michael E. Cox

Journal:

Year:

2010

Language:

english

File:

PDF, 470 KB

english, 2010

26

10.1038/4362

Matveeva, Olga, Felden, Brice, Tsodikov, Alexander, Johnston, Joseph, Monia, Brett P., Atkins, John F., Gesteland, Raymond F., Freier, Susan M.

Journal:

Nature Biotechnology

Year:

1998

Language:

english

File:

PDF, 138 KB

english, 1998

27

10.1038/5476

Monia, Brett P.

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 57 KB

english, 1999

28

New Perspectives on the Structure and Function of Ubiquitin

Monia, Brett P., Ecker, David J., Crooke, Stanley T.

Journal:

Year:

1990

File:

PDF, 946 KB

1990

29

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

Monia, Brett P., Johnston, Joseph F., Geiger, Thomas, Muller, Marcel, Fabbro, Doriano

Journal:

Nature Medicine

Year:

1996

File:

PDF, 1.06 MB

1996

30

Antisense therapy for cancer

Gleave, Martin E., Monia, Brett P.

Journal:

Nature Reviews Cancer

Year:

2005

Language:

english

File:

PDF, 462 KB

english, 2005

31

Antisense transcripts are targets for activating small RNAs

Schwartz, Jacob C, Younger, Scott T, Nguyen, Ngoc-Bich, Hardy, Daniel B, Monia, Brett P, Corey, David R, Janowski, Bethany A

Journal:

Nature Structural and Molecular Biology

Year:

2008

Language:

english

File:

PDF, 471 KB

english, 2008

32

Inhibition of Bcl-xL expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli

Taylor, Jennifer K, Zhang, Qing Qing, Monia, Brett P, Marcusson, Eric G, Dean, Nicholas M

Journal:

Year:

1999

Language:

english

File:

PDF, 408 KB

english, 1999

33

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells

Choi, Yong, Zhang, Jie, Murga, Cristina, Yu, Hong, Koller, Erich, Monia, Brett P, Gutkind, J Silvio, Li, Weiqun

Journal:

Year:

2002

Language:

english

File:

PDF, 270 KB

english, 2002

34

Inhibition of hepatic sulfatase-2 In Vivo: A novel strategy to correct diabetic dyslipidemia

H. Carlijne Hassing, Hans Mooij, Shuling Guo, Brett P. Monia, Keyang Chen, Wim Kulik, Geesje M. Dallinga-Thie, Max Nieuwdorp, Erik S.G. Stroes, Kevin Jon Williams

Journal:

Year:

2012

Language:

english

File:

PDF, 489 KB

english, 2012

35

STAT3 Regulates the Growth and Immunoglobulin Production of BCL1 B Cell Lymphoma through Control of Cell Cycle Progression

James G. Karras, Robert A. McKay, Tao Lu, Jaclyn Pych, David A. Frank, Thomas L. Rothstein, Brett P. Monia

Journal:

Cellular Immunology

Year:

2000

Language:

english

File:

PDF, 252 KB

english, 2000

36

Reversal of cisplatin resistance in human ovarian cancer cell lines by a c-jun antisense oligodeoxynucleotide (ISIS 10582): evidence for the role of transcription factor overexpression in determining resistant phenotype

Bin Pan, Kang-Shen Yao, Brett P. Monia, Nicholas M. Dean, Robert A. McKay, Thomas C. Hamilton, Peter J. O’Dwyer

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 347 KB

english, 2002

37

Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells

Michelle Garay, William Gaarde, Brett P. Monia, Pamela Nero, Catherine L. Cioffi

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 613 KB

english, 2000

38

Novel mechanisms for antisense-mediated regulation of gene expression

Brenda F Baker, Brett P Monia

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1999

Language:

english

File:

PDF, 265 KB

english, 1999

39

Discovery and Analysis of Antisense Oligonucleotide Activity in Cell Culture

Brenda F. Baker, Thomas P. Condon, Erich Koller, Robert A. McKay, Andrew M. Siwkowski, Timothy A. Vickers, Brett P. Monia

Journal:

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

40

Cellular and molecular pharmacology of auranofin and related gold complexes

Stanley T. Crooke, Rosanne M. Snyder, Tauseef R. Butt, David J. Ecker, H.S. Allaudeen, Brett Monia, Christopher K. Mirabelli

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 769 KB

english, 1986

41

PKCε plays a causal role in acute ethanol-induced steatosis

J. Phillip Kaiser, Juliane I. Beier, Jun Zhang, J. David Hoetker, Claudia von Montfort, Luping Guo, Yuting Zheng, Brett P. Monia, Aruni Bhatnagar, Gavin E. Arteel

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 580 KB

english, 2009

42

Antisense Knockdown of Kras Inhibits Fibrosis in a Rat Model of Unilateral Ureteric Obstruction

Jia-Hui Wang, Lucy J. Newbury, A.S. Knisely, Brett Monia, Bruce M. Hendry, Claire C. Sharpe

Journal:

The American Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 2.00 MB

english, 2012

43

Mcl-1 overexpression in hepatocellular carcinoma: A potential target for antisense therapy

Wolfgang Sieghart, Doris Losert, Sabine Strommer, Daniel Cejka, Katharina Schmid, Susanne Rasoul-Rockenschaub, Martin Bodingbauer, Richard Crevenna, Brett P. Monia, Markus Peck-Radosavljevic, Volker W

Journal:

Journal of Hepatology

Year:

2006

Language:

english

File:

PDF, 242 KB

english, 2006

44

Elucidating cell signaling mechanisms using antisense technology

Erich Koller, William A Gaarde, Brett P Monia

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 127 KB

english, 2000

45

Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice

Yin Liang, Melville C. Osborne, Brett P. Monia, Sanjay Bhanot, Lynnetta M. Watts, Pengxiang She, Stephanie O. DeCarlo, Xiaoli Chen, Keith Demarest

Journal:

Year:

2005

Language:

english

File:

PDF, 181 KB

english, 2005

46

Leukotriene Receptors and Mechanisms of Signal Transduction

STANLEY T. CROOKE, BRETT P. MONIA, MING YI CHIANG, C. FRANK BENNETT

Journal:

Annals of the New York Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 287 KB

english, 1991

47

Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice

Karras, James G., Crosby, Jeffrey R., Guha, Mausumee, Tung, David, Miller, Doreen A., Gaarde, William A., Geary, Richard S., Monia, Brett P., Gregory, Susan A.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.62 MB

english, 2007

48

Comparing In Vitro and In Vivo Activity of 2′- O -[2-(Methylamino)-2-oxoethyl]- and 2′- O -Methoxyethyl-Modified Antisense Oligonucleotides

Prakash, Thazha P., Kawasaki, Andrew M., Wancewicz, Edward V., Shen, Lijiang, Monia, Brett P., Ross, Bruce S., Bhat, Balkrishen, Manoharan, Muthiah

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

49

Peptide Nucleic Acids Conjugated to Short Basic Peptides Show Improved Pharmacokinetics and Antisense Activity in Adipose Tissue

Wancewicz, Edward V., Maier, Martin A., Siwkowski, Andrew M., Albertshofer, Klaus, Winger, Theodore M., Berdeja, Andres, Gaus, Hans, Vickers, Timothy A., Bennett, C. Frank, Monia, Brett P., Griffey, R

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

50

Identification of REST-Regulated Genes and Pathways Using a REST-Targeted Antisense Approach

Sedaghat, Yalda, Bui, Huynh-Hoa, Mazur, Curt, Monia, Brett P.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2013

Language:

english

File:

PDF, 864 KB

english, 2013

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